Semax

Semax is a synthetic peptide analog of ACTH (adrenocorticotropic hormone), specifically a modified fragment of the ACTH(4-10) sequence. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been a registered pharmaceutical in Russia and Ukraine since 1996. It is one of the few peptides with a documented history of clinical use, though it remains unapproved by the FDA in the United States.

Semax research has focused primarily on cognitive function and neuroprotection. Published studies have investigated its effects on BDNF (brain-derived neurotrophic factor) expression, NGF (nerve growth factor) levels, and neurotransmitter systems including dopamine and serotonin. In Russian clinical literature, it has been studied in the context of stroke recovery, cognitive impairment, and optic nerve conditions. Preclinical research has also explored its effects on immune function and inflammation.

Standard Semax is the base ACTH(4-10) analog. NA-Semax (N-Acetyl Semax) adds an acetyl group, which researchers believe improves stability and may enhance BDNF-related activity. NASA-Semax (N-Acetyl Semax Amidate) adds both an acetyl group and an amide group, making it the most modified version with potentially longer duration of activity. Each modification changes the pharmacokinetic profile. Kern carries standard Semax, which is the most widely studied form in published literature.

In published research, Semax demonstrates rapid absorption with effects observed within 30 minutes of intranasal administration in animal models. Duration of activity ranges from 2 to 10 hours depending on the dose and route. The peptide crosses the blood-brain barrier, which is unusual for peptides of this size and contributes to its rapid onset in CNS-related research.

Store lyophilized Semax at -20C for long-term stability (24+ months). Reconstituted Semax should be refrigerated at 2-8C and used within 4-6 weeks. If prepared as a nasal solution, shelf life may be shorter depending on the formulation. Protect from light and heat.

Semax is not FDA-approved and is not available as a prescription medication in the US. It is classified as a research chemical and is legal to purchase for laboratory and in vitro research. In Russia and Ukraine, it is a registered and regulated pharmaceutical product.

Every batch undergoes third-party HPLC and mass spectrometry testing. HPLC confirms purity (99%+ standard). Mass spectrometry confirms molecular identity. A batch-specific Certificate of Analysis is provided with every purchase and available for download directly on this page.

All Kern products ship same-day (orders placed before 1pm EST). Lyophilized peptides are shipped at ambient temperature and are stable during transit. Upon receipt, store at -20C for long-term stability or 2-8C for near-term use. If the product arrives damaged, contact us within 7 days with photos for a free replacement.

Price differences usually reflect differences in purity, testing standards, and manufacturing quality. Low-cost vendors may skip mass spectrometry verification (which confirms you actually have the right molecule), use lower-grade raw materials, or skip sterility and endotoxin testing. Kern tests every batch with both HPLC and mass spec, and our CoAs are available before you buy.