Tesamorelin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of all 44 amino acids of human GHRH with an added trans-3-hexenoic acid group at the N-terminus. The FDA-approved version (Egrifta) is indicated for the reduction of excess abdominal fat in HIV-associated lipodystrophy. It is one of the few GH secretagogues with FDA approval for any indication. The research-grade form is used for in vitro and preclinical studies.

Both are GHRH analogs but differ in pharmacokinetics and regulatory status. Tesamorelin is FDA-approved (for HIV lipodystrophy), has a shorter half-life requiring daily administration, and has the strongest published evidence for visceral fat reduction. CJC-1295 (especially with DAC) has an extended half-life allowing less frequent dosing but lacks FDA approval and has fewer published clinical studies. Tesamorelin has the deeper evidence base; CJC-1295 offers more practical dosing flexibility.

Phase 3 clinical trials demonstrated a 15% reduction in visceral adipose tissue after 26 weeks of daily 2mg subcutaneous administration, with results maintained through 52 weeks of treatment. These are among the most robust clinical data available for any GH secretagogue in the context of body composition research.

The FDA label for Egrifta lists injection-site reactions, itching, joint pain (arthralgia), muscle pain (myalgia), and peripheral edema as the most common adverse events. The compound is generally well-tolerated in published clinical data.

Emerging research has investigated Tesamorelin's effects on cognitive function and neurodegeneration biomarkers. Some studies have reported improvements in cognitive markers, but this research is still preliminary. The compound's primary evidence base remains in body composition and metabolic health.

Store lyophilized Tesamorelin at -20C. Reconstitute with bacteriostatic water and refrigerate at 2-8C. Use reconstituted vials within 30 days.

Every batch undergoes third-party HPLC and mass spectrometry testing. HPLC confirms purity (99%+ standard). Mass spectrometry confirms molecular identity. A batch-specific Certificate of Analysis is provided with every purchase and available for download directly on this page.

All Kern products ship same-day (orders placed before 1pm EST). Lyophilized peptides are shipped at ambient temperature and are stable during transit. Upon receipt, store at -20C for long-term stability or 2-8C for near-term use. If the product arrives damaged, contact us within 7 days with photos for a free replacement.

Price differences usually reflect differences in purity, testing standards, and manufacturing quality. Low-cost vendors may skip mass spectrometry verification (which confirms you actually have the right molecule), use lower-grade raw materials, or skip sterility and endotoxin testing. Kern tests every batch with both HPLC and mass spec, and our CoAs are available before you buy.