PT-141

PT-141 (Bremelanotide) is a melanocortin receptor agonist derived from Melanotan II. It selectively targets MC3R and MC4R receptors in the central nervous system, which are involved in sexual arousal and desire. An FDA-approved version (Vyleesi) was approved in 2019 for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. The research-grade form is used for in vitro and preclinical studies.

The pharmaceutical version (Bremelanotide, brand name Vyleesi) is FDA-approved specifically for HSDD in premenopausal women. It is not approved for use in men or for general sexual function enhancement. Research-grade PT-141 is a separate product sold exclusively for laboratory and in vitro research purposes. For Research Use Only.

PDE5 inhibitors (such as sildenafil and tadalafil) work by increasing blood flow through vasodilation. They address the mechanical/vascular component of sexual function. PT-141 works in the central nervous system by activating melanocortin receptors involved in sexual desire and arousal. It operates upstream at the level of desire rather than downstream at the level of blood flow. These are fundamentally different mechanisms.

In the clinical trials that led to FDA approval, nausea was the most common side effect, occurring in approximately 40% of subjects. Other reported effects include headache, flushing, transient blood pressure elevation, and mild hyperpigmentation with repeated administration. The 12-month safety extension study includes a warning about blood pressure effects and limits use to no more than 8 administrations per month.

PT-141 selectively targets MC3R and MC4R (sexual function pathways) with minimal MC1R activation (pigmentation). Melanotan II activates all melanocortin receptor subtypes broadly, producing both tanning and sexual function effects along with appetite suppression. PT-141 was developed specifically to isolate the sexual function response.

Store lyophilized PT-141 at -20C. Reconstitute with bacteriostatic water and refrigerate at 2-8C. Use reconstituted vials within 30 days.

Every batch undergoes third-party HPLC and mass spectrometry testing. HPLC confirms purity (99%+ standard). Mass spectrometry confirms molecular identity. A batch-specific Certificate of Analysis is provided with every purchase and available for download directly on this page.

All Kern products ship same-day (orders placed before 1pm EST). Lyophilized peptides are shipped at ambient temperature and are stable during transit. Upon receipt, store at -20C for long-term stability or 2-8C for near-term use. If the product arrives damaged, contact us within 7 days with photos for a free replacement.

Price differences usually reflect differences in purity, testing standards, and manufacturing quality. Low-cost vendors may skip mass spectrometry verification (which confirms you actually have the right molecule), use lower-grade raw materials, or skip sterility and endotoxin testing. Kern tests every batch with both HPLC and mass spec, and our CoAs are available before you buy.